However, at Fertil-In we are optimistic! We seek out and use leads whose results seem promising.
It was observed, in a group of women suffering from endometriosis and in comparison with a group of women who did not have this pathology, immune variations.
In women with endometriosis, a higher ratio between TH17 lymphocytes and CD25 + lymphocytes was observed, especially in the blood. A configuration prevalent in most autoimmune diseases.
We can therefore suspect an anarchic immune activity in endometriosis. However, there is a curiosity. This previously cited ratio seems to be completely reversed in the peritoneal fluid level near the areas affected by endometriosis.
In this tissue, immunity would seem more to allow an anarchic proliferation of cells with greatly increased CD25 +.
2. Excessive inflammation
Inflammation in the body is initially a benign process, aimed at recruiting cells to repair tissue.
Once the tissue goes into "repair" mode, through molecules like resolvins for example, the inflammation stops.
So why does the inflammation become chronic in the endometriosis? We have followed two major leads.
The first is a lack of repair "material". Knowing that resolvins are produced from omega 3 fatty acids, we immediately acted on this path, which, moreover has been strongly supported by the science.
The second: endometrial tissue is tissue infiltrated by immune cells, mast cellswhich themselves produce molecules that are pro-inflammatory and decongestant for the tissue. This tissue is therefore poorly drained and has little chance of becoming without specific immune action. Therefore, we offer strict, but short actions aimed at reducing immune infiltration and helping tissue to drainage.
3. The way out
We know that endometriosis has a potential way out, which is pregnancy!
With endometriosis, pregnancy and breastfeeding tend to bring a calming and sometimes healing effect, probably through their immune and hormonal action.
The goal is therefore clear: to decrease the activity of endometrial tissue, until a first pregnancy. Then, recommend prolonged breastfeeding to follow on a second pregnancy, then prolonged breastfeeding .... and so on. There is therefore a chance, later, that the endometrial tissue becomes "inactive" and in this case, it is victory!
Beyond having beneficial effects on the mother's endometriosis, breastfeeding also seems to reduce the risk of developing this disease in the child by 3, if it is a girl.
What if reducing endometriosis over several generations was due to lifestyle factors?
Of course, if this is not an option for you and the pain becomes unbearable, then you could discuss potential surgery or other treatments with your gynecologist.
We believe that endometriosis is a condition that is also regulated by the field. Although it is not completely reversible by the lifestyle changes, it is controllable! Taking back the reins of such an invasive pathology feels good!
 Khan, K. N., Yamamoto, K., Fujishita, A., Muto, H., Koshiba, A., Kuroboshi, H., Saito, S., Teramukai, S., Nakashima, M., & Kitawaki, J. (2019). Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis. The Journal of clinical endocrinology and metabolism, 104(10), 4715–4729. doi.org/10.1210/jc.2019-00350
 Podgaec, S., Rizzo, L. V., Fernandes, L. F., Baracat, E. C., & Abrao, M. S. (2012). CD4(+) CD25(high) Foxp3(+) cells increased in the peritoneal fluid of patients with endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989), 68(4), 301–308. doi.org/10.1111/j.1600-0897.2012.01173.x
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 Binda, M. M., Donnez, J., & Dolmans, M. M. (2017). Targeting mast cells: a new way to treat endometriosis. Expert opinion on therapeutic targets, 21(1), 67–75. doi.org/10.1080/14728222.2017.1260548
 Farland LV, Eliassen AH, Tamimi RM, Spiegelman D, Michels KB, Missmer SA. History of breast feeding and risk of incident endometriosis: prospective cohort study. BMJ. 2017 Aug 29;358:j3778. doi: 10.1136/bmj.j3778. PMID: 28851765; PMCID: PMC5574033.
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