Unexplained infertility: what if the problem came from elsewhere?

In consultation, facing these couples, we feel and understand it so much, it is such a pain, not to know!
Sometimes they blame the doctors, and then they understand that the doctor has nothing to do with it, that he cannot explain their infertility, because there is simply no medical explanation.
In an interview, a couple tells Adva: “We don't understand how you can talk about unexplained infertility. It’s as if we took our car to the mechanic and he explained to us that he had checked everything and that the failure was unexplained. So he didn't know how to fix it. How can you say that! We used to feel like we were going through it without being able to act. And now we feel helplessness in the face of the situation." 

This metaphor says a lot about the desperation and frustration of people who come to us. So we thought that this metaphor was very interesting and that we had to do something with it. This is how our video Unexplained Infertility was born.

Reproductive medicine is one of the most progressive, it is sophisticated and particularly technical. As the name suggests, it is medical, so it is rightly based on medical diagnoses. It therefore only takes into account the studies and indices proven during extremely strict protocols.

However, if infertility is medically unexplained, shouldn't we look elsewhere? In terms of the field, for example?

But what is the field? Well, it is your physiological basis or fondation of two of you, that are going to conceive a child. It's how your system balances, uses nutrients, produces energy, produces hormones, defends itself, intoxicates, detoxifies, or self-regulates.
To synthesize, it is the underlying potential that will contribute, through many factors, to the quality of your gametes (oocytes and spermatozoa), but also to the implantation process.

And finally, shouldn't we ask ourselves this question: Could unexplained infertility be linked to the factors in the field?

At Fertil-In, we searched a lot, and also found a lot, very interesting elements and leads. We have applied them too, with the contribution of voluntary testers.

Today we would like to tell you about two avenues among those that we have retained and included in our programs, but obviously in a personalized way. So only, if the answers to the questionnaire of the "Fertil-In" programs indicate risk factors on these different factors:

Factor 1: Deficiencies

It is unlikely that a single deficiency will lower fertility, although some publications focusing on a mineral like selenium[1] or iodine [2], either in men or in women[3] seem timidly support this element. However, several scientific reviews focus on factors of combined deficiency and imbalance[4].

In clinical practice, in nutrition, we see that choosing a better type of fat consumed and a higher nutritional density (rich in vitamins and minerals) can improve the factors in the field, linked to infertility.
In addition, more and more gynecologists and reproductive physicians are rightly adopting the reflex of establishing supplementation. However, it must be taken into account that it is not that simple because if, for example, you introduce a food supplement based on omega 3 fatty acids and your diet remains too rich in saturated fat, this supplement alone will not will not be enough to restore a balance. And then it will be very likely that you bought it and ended up with a poor result.

This may make you think that it is a combination of factors that can improve the fertility.

Factor 2: Immunity

This is a field factor that we love to talk about.

The first precise publication on the link between immunity and unexplained infertility dates from 2006[5]. It focuses on the role of immune cells that contribute in a very specific way to the acceptance of pregnancy, the Regulatory T lymphocytes. These cells do not regulate the ground only for pregnancy, but also for autoimmune diseases and cancerous processes. They are the conductors of our immunity and keep it from getting out of hand.
Several more recent publications support this immune pathway in the context of infertility, but also in polycystic ovary syndrome[6]endometriosis[7]transfer failures [8] and early miscarriages[9].

We therefore understand that immunity seems to be an element in the field, perhaps not for all unexplained infertility (be careful, no false generalities!), but probably for many!
We also know that these famous Tregs can be out of balance in people with allergies or autoimmune diseases. There are therefore interesting risk factors that we have clearly taken into account in the programs.

There are also many ways to balance these cells, but often they are indirect and it is therefore necessary to find the right levers such as reduction of stress, management of sleep and certain deficiencies, immune imbalances, digestive dysfunctions or even infections.
Immunity is a system that is supposed to be self-balancing. If it no longer does so, then we must understand why and therefore seek the factors on the ground on which we must act.

While reproductive medicine offers answers to the medical causes of infertility, a hands-on approach can give you leads on medically unexplained infertility.

In this video, we discuss the other field factors we are working on in our programs.
We let you discover them and maybe decide to activate the change!

Notes :

[1] Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice, 2019 Dec 11, www.ncbi.nlm.nih.gov/pubmed/31835711#

[2] The association between iodine intake and semen quality among fertile men in China, 2020 Apr 6, www.ncbi.nlm.nih.gov/pubmed/32252717

[3] Delayed conception in women with low-urinary iodine concentrations: a population-based prospective cohort study, 2018 Mar 1, www.ncbi.nlm.nih.gov/pubmed/29340704

[4] Nutrition and fertility, 2018 Sep 7, www.ncbi.nlm.nih.gov/pubmed/30351153

[5] Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue, 2006 May, www.ncbi.nlm.nih.gov/pubmed/16574699

[6] T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome, 2018 Sep, www.ncbi.nlm.nih.gov/pubmed/30246693

[7] Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate, 2012 Jun, www.ncbi.nlm.nih.gov/pubmed/22442246

[8] Downregulation of ILT4+ dendritic cells in recurrent miscarriage and recurrent implantation failure, 2018 Oct, www.ncbi.nlm.nih.gov/pubmed/29904967

[9] Low levels of naturally occurring regulatory T lymphocytes in blood of mares with early pregnancy loss, 2014, www.ncbi.nlm.nih.gov/pubmed/23787006

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